FluQuadri Vaccine (SH-2021 formula) Inactivated quadrivalent flu vaccine

FluQuadri Vaccine (SH-2021 formula) Inactivated quadrivalent flu vaccine.

FluQuadri Vaccine (SH-2021) formula is an inactivated influenza vaccine. It is a split virion vaccine. It is a tetravalent vaccine. It contains 4 types of antigens from influenza virus species. This is a vaccine from Sanofi Pasteur India pvt ltd.

This vaccine does not contain any preservatives or thiomersal.

Depending on predicted flu virus, countries are divided as southern hemisphere and northern hemisphere strains. This year in 2021 most part of india is southern hemisphere tropical zone,

This vaccine contains Influenza virus A (H1N1) strain, A(H3N2) strain, Influenza B virus (Victoria lineage) strain, Influenza C virus (Yamagata lineage) strains.

FluQuadri Vaccine (SH-2021) Vaccine (SH-2021) for intramuscular injection is an inactivated influenza vaccine. It is prepared from influenza viruses that are propagated on embryonated chicken eggs. The virus containing allantoic fluid is harvested and inactivated with formaldehyde. Influenza virus is concentrated and purified. 

Then the virus is chemically disrupted using a non ionic surfactant. Split virus is further purified and suspended in sodium phosphate-buffered isotonic sodium chloride solution. 

An additional step is used to further increase the concentration of HA. Antigens from four strains are produced separately and combined to make the quadrivalent formulation.

Quantity per dose
IngredientFluQuadri 0.25 mlFluQuadri 0.5 ml
Active substance split influenza virus Inactivated strains30 mcg HA total60 mcg HA total
A (H1N1)7.5 mcg HA15 mcg HA
A (H3N2)7.5 mcg HA15 mcg HA
B (Victoria lineage)7.5 mcg HA15 mcg HA
B (Yamagata lineage)7.5 mcg HA15 mcg HA
Sodium phosphate buffered isotonic sodium chloride solutionqs appropriate to volumeqs appropriate to volume
Formaldehyde< 50 mcg< 100 mcg
Octylphenol ethoxylate< 125 mcg< 250 mcg
Contents of FluQuadri Vaccine

How is the FluQuadri Vaccine (SH-2021) Vaccine (SH-2021) vaccine available?

FluQuadri Vaccine (SH-2021) Vaccine (SH-2021) vaccine is available in ready to inject formulation as a slightly opalescent liquid form. It is available in a prefilled sterile syringe for injection. It is available in dose 0.25 ml and 0.5 ml. It is available in single dose packet.

How is the FluQuadri Vaccine (SH-2021) Vaccine (SH-2021) vaccine stored?

FluQuadri Vaccine (SH-2021) Vaccine (SH-2021) vaccine is stored at 2-8 degree Celsius as recommended by the manufacturer. Temperature range is maintained by the cold chain. The vaccine if accidentally frozen should be discarded and not used. The temperature range is maintained at all stages of storage and transport.

How is FluQuadri Vaccine (SH-2021) Vaccine (SH-2021) vaccine given?

FluQuadri Vaccine (SH-2021) Vaccine (SH-2021) vaccine is given by injection on the anterolateral aspect of the thigh in infants and small children. For adults and adolescents it can be given on the deltoid region of the shoulder. All standard safe injection precautions need to be taken. After use the disposables and needles are to be discarded as per the guidelines for biomedical waste management protocols. The expired vaccine should be discarded as per BMW protocols so that it is not harmful to the environment. The dose for those below 3 years is 0.25 ml and those above 3 years is 0.5 ml

At what age FluQuadri Vaccine (SH-2021) Vaccine (SH-2021) vaccine is given?

FluQuadri Vaccine (SH-2021) Vaccine (SH-2021) vaccine is given at age 6 months and second dose at 7 months then one dose is given yearly till 5 years of age. Children with chronic pulmonary diseases and those with increased chances of pulmonary infection this dose should be given yearly. Those adults who are diabetic and hypertensive and immunosuppressed should get this vaccine yearly. This vaccine is used in pregnancy as there is an increased risk of wine flu during pregnancy.

6 months through 35 monthsOne or 2 doses 0.25 ml eachIf 2 doses administer at least 4 weeks apart
36 months through 8 yearsOne or 2 doses 0.5 ml eachIf 2 doses administer at least 4 weeks apart
9 years and olderOne dose, 0.5 ml 
Schedule of FluQuadri vaccine

How does the FluQuadri Vaccine (SH-2021) Vaccine (SH-2021) vaccine work?

FluQuadri Vaccine (SH-2021) Vaccine (SH-2021) is a killer vaccine. It contains split particles of virus. This is an active form of immunization. When this vaccine is injected to an individual the antigens in it get inside the body. These antigens are recognized by the immune system of the individuals. The immune system develops mechanisms to fight against the virus and if real infection takes place the immune response is rapidly ramped up and the disease is prevented. Only the drawback is influenza virus mutates rapidly and so because of this, the new version of vaccine comes yearly. It needs to be given yearly.

What are the side effects of the FluQuadri Vaccine (SH-2021) Vaccine (SH-2021) vaccine?

Side effects of FluQuadri Vaccine (SH-2021) Vaccine (SH-2021) vaccine are usually mild and can be managed at home very easily

  • Fever can be there after the vaccination. It can be mild to moderate grade and can be managed at home by paracetamol and sponging. Fever may last for 1-3 days usually reduces with time.
  • Local pain and redness, swelling can come at the injection site. It may last for 1-3 days. It can be easily managed with paracetamol and local cold fomentation.
  • Headache can come in some patients after vaccination. Usually reduces in 1-3 days. This headache can be managed at home with paracetamol.
  • Irritability and abnormal crying.
  • Loss of appetite and vomiting.
  • Muscular pain and fatigue seen after FluQuadri Vaccine (SH-2021) Vaccine (SH-2021) vaccination may last for 1-3 days. It generally reduces on its own.
  • Allergy and anaphylactic reaction: This is a very rare side effect. The vaccine should not be given to those who are allergic to the component/s of the vaccine. The anaphylactic reaction should be managed very swiftly. The skilled person, necessary drugs and equipment should be available for the management.

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