Nimenrix a meningococcal meningitis conjugate vaccine

Nimenrix a Meningococcal meningitis conjugate vaccine

Nimenrix vaccine is used to prevent the Meningococcal Meningitis disease. It is vaccine by GSK pharma. It is a Killed Meningococcal vaccine.

Nimenrix Meningococcal Meningitis Vaccine is a vaccine indicated for active immunization to prevent invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, Y, and W-135.

This is tetanus toxoid Conjugate Vaccine.

The Neisseria meningitidis serogroups A and C polysaccharides are conjugated with an adipic dihydrazide (AH) spacer and indirectly conjugated to the tetanus toxoid whereas the W-135 and Y polysaccharides are conjugated directly to tetanus toxoid.

This vaccine does not contain any preservatives.

Active ingrediantsQuantity
Neisseria meningitidis serogroup A
5 mcg
Neisseria meningitidis serogroup C
5 mcg
Neisseria meningitidis serogroup W-135
5 mcg
Neisseria meningitidis serogroup Y
5 mcg

Additionally it also has Sucrose, Trometamol, Sodium chloride.

Nimenrix Meningococcal Meningitis Vaccine is approved for use in persons 1 years of age. Nimenrix Meningococcal Meningitis Vaccine does not prevent N. meningitidis serogroup B infections.

This vaccine is available in 0.5 ml dosages.

How is Nimenrix Meningococcal Meningitis vaccine available?

Nimenrix Meningococcal Meningitis Vaccine is available as injection liquid form.

The active components in powder form is available in vial. Diluent is available in pre filled syringe.

It is available as 0.5 ml dose. It is available in single dose form.

Keep the product in outer box provided with it to protect from sun light.

Reconstitute just before injection.

How to store Nimenrix Meningococcal Meningitis vaccine?

Store the Nimenrix Meningococcal Meningitis Vaccine at 2-8 degree Celsius. Strictly maintain temperature range with the help of cold chain.

Maintain the temperature range at all levels of transport and storage.

Do not freeze the vaccine. Discard if frozen accidentally or the temperature range is exceeded.

Discard the product that has passed the expiry date.

Follow all the local biomedical waste management protocols while discarding vaccine.

How to give Nimenrix Meningococcal Meningitis vaccine?

Reconstitute Nimenrix vaccine by pushing the diluent in pre filled syringe in powder containing vial.

Give Nimenrix vaccine on anterolateral aspect of thigh in small children and in shoulder in adult in deltoid muscle.

Follow all the safety injection precautions while giving injection.

Discard the disposables as per biomedical waste management protocols. Discard the vaccine that has passed expiry date

For those who have bleeding disorder this vaccine can be administered subcutaneously and firm pressure is given after the vaccination. The vaccination should be preferably planned after getting the dose of clotting factor in haemophilliacs.

At what age Nimenrix Meningococcal Meningitis vaccine is given?

Primary Immunization

Primary series 2 doses of vaccine 2 months apart at 2 and 4 month of age can be given.


A single dose booster is given at age 12 months or above.

NIMENRIX may be given as a booster dose to individuals who have previously received primary vaccination with NIMENRIX or other conjugated or plain polysaccharide meningococcal vaccines.

How does Nimenrix Meningococcal Meningitis vaccine works?

Nimenrix Meningococcal Meningitis Vaccine is a killed vaccine. Use it to prevent the infection and inflammation caused by Neisseria meningitidis serogroups A, C, Y, and W-135.

This Neisseria meningitidis infects the meninges the thin covering of the brain and causes disease meningitis which is life threatening in many cases even after treatment.

This vaccination is active form of immunization and inject adequate doses to someone the immunity of the host recognizes the antigens in this vaccine as foreign antigens and form immune response against these antigens.

When given as per schedule in adequate doses as suggested body also develops long term immunity in the process.

When the real infection occurs the body fights the infection more vigorously and prevents disease. Thus this is active form of immunization.

Safety with other vaccine:

Nimenrix Meningococcal Meningitis Vaccine is safe with most other medicine and no drug interactions were noted.

Do not mix the other vaccine or other drug in same syringe as this vaccine.

Whenever possible, co-administer NIMENRIX and a tetanus toxoid (TT) containing vaccine, such as DTaP-HBV-IPV/Hib vaccine

Or Administer Nimenrix at least one month before TT containing vaccine

Like other inactivated vaccines Nimenrix Meningococcal Meningitis Vaccine is considered as safe in pregnant and lactating woman, but the risk benefit ratio should be evaluated by the caregiver.

Concomitant administration of Hepatitis a, hepatitis B and MMR vaccine and also HiB vaccine is safe with Nimenrix Meningococcal Meningitis Vaccine.

This vaccine is also safe when given with diphtheriapertussisHiB and pneumococcal vaccines.

What are side effects of Nimenrix Meningococcal Meningitis vaccine?

This Menongococcal Meningitis Vaccine causes side effect that are generally milder and can be managed at home and does not need hospital admission:

  • · Fever is common side effect after the vaccination. It usually subsides in 1-3 days and can be managed very easily at home with medicine like paracetamol and sponging.
  • Swelling and pain occurs at injection site may last for 1-3 days. Manage it with paracetamol and local cold compression.
  • Diarrhea and loss of appetite can occur after vaccination and can be managed by oral rehydrating solution.
  • Nausea and vomiting may occur after the vaccination and it can be managed by oral syp ondansetron and oral rehydrating solution.
  • Muscular pain and joint pain.
  • Headache and fatigue.
  • Anaphylaxis and allergy is extremely rare side effect of the vaccine. Like other vaccines the vaccine should be administered at center where necessary personnel and drugs and equipments are available to manage if any reaction occurs.

<span class="has-inline-color has-luminous-vivid-orange-color">Dr Yatin Bhole MBBS DCh DNB</span>
Dr Yatin Bhole MBBS DCh DNB

This article was written by Dr Yatin Bhole who is practicing Pediatrician at Bhole Children Clinic, Ravet. This post is for general information and before applying it on yourself, you should meet your doctor or meet us in person.

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