Tresivac (pfs) vaccine (MMR Vaccine)

Tresivac (pfs) vaccine (MMR Vaccine)

Tresivac (pfs) vaccine is a brand of MMR Vaccine by Serum Institute of India. This vaccine protects against measles, mumps and rubella these 3 diseases. This is live attenuated vaccine. It contains live attenuated measles virus Edmonston-Zagreb strain (propagated in human diploid cell cultures), live attenuated L-zagreb mumps virus strain (propagated in chick embryo fibroblast cell culture), live attenuated rubella virus Wistar RA27/3 strain (propagated in human diploid cells). It contains sterile water for injection 0.5 ml.

How is Tresivac (pfs) vaccine available?

Tresivac pfs vaccine is available as pre-filled syringe. The lyophilized powder is available is a separate vial. The pre-filled syringe contains sterile water to be mixed with lyophilized powder. The vaccine is in opaque paper packet. It should be stored in the packaging it comes with.

How is Tresivac (pfs) vaccine prepared?

Tresivac pfs vaccine, sterile water for injection is mixed with lyophilized powder. The needle should be attached to the syringe of sterile water. The water is pushed into the vial of lyophilized powder. The mixture is agitated gently to mix the content. The care should be taken while doing the procedure that sterilizers and disinfectant should not touch the vial. The care should be taken to avoid the needle prick while mixing the contents. The mixture is sucked buck into the syringe.

How the Tresivac (pfs) vaccine can be given?

Tresivac pfs vaccine can be given either by subcutaneous route. All the safety injection precautions need to be taken while giving injection. The disinfectant applied to skin should be evaporated completely before giving the injection. The disposables after use of injection should be discarded as per biomedical waste management protocols. The vaccine if expired should be discarded and not used. The expired vaccines need to be discarded as per biomedical waste management protocols.

At what age Tresivac (pfs) vaccine is given?

Tresivac pfs vaccine is given at age 6-9 months and the next dose is given at 15 months followed by at 5 years of age in routine immunization schedule.

What if someone has missed Tresivac (pfs) vaccine dose?

If unvaccinated person above 9 months comes to OPD, Tresivac pfs vaccine is the priority vaccine to be given. The missed dose should be given as early as possible. The opinion of pediatrician is to be taken before vaccination. In adults the side effects are comparatively more like fever and bilateral parotid swelling.

Safety with other vaccines:

  • Though the vaccine is safe with other vaccines it should not be mixed in same syringe as the other vaccine.
  • This vaccine can be safely given with dT, TT, DPT, DTaP, Tdap, Typhoid vaccine, hepatitis B, yellow fever vaccine, vitamin A dose, HiB vaccine, BCG and polio vaccines.

How does Tresivac (pfs) vaccine works?

Tresivac pfs vaccine contains live attenuated viruses of measles, mumps and rubella. Live attenuated means these are live virus but they lack capacity to cause disease though they have capacity to infect. When these viruses are injected by vaccine they infect the person who got the injection. They multiply in the body of the host. The immunity of the host recognizes these viruses. The immunity develops mechanism to fight these viruses. In this process the body also develops the memory immunity. When the real infection of these diseases occur the body rapidly increases the immune response and the disease is prevented. This is active form of immunization.

What are the side effects of the Tresivac (pfs) vaccine?

Side effects of Tresivac (pfs) vaccine are usually milder when compared to the diseases it cause. Common side effects are:

  • Fever may come and usually lasts for 1-3 days and it can be easily controlled by oral medications like paracetamol at home.
  • Skin rash which looks like measles disease can appear in few days after vaccination. This rash is usually milder and short lasting than measles disease.
  • Pain, swelling and redness at injection site. This may come after injection and may last for 1-3 days. It usually subsides by its own or by simple measures like local cold fomentation.
  • Symptoms of upper respiratory tract infection like cold and running nose.
  • Nervousness and crying.
  • Lymphadenopathy: Uncommon.
  • Conjuctivitis, bronchitis, parotid gland swelling, diarrhea and vomiting are uncommon side effects. These are usually milder and are generally manageable on OPD basis at home.
  • In adults the reactions like bilateral parotid swelling and fever reactions are common to children.
  • Thrombocytopenia is rare side effects and if occurs it usually resolves by its own.
  • Like all other vaccine anaphylaxis reaction may come after this vaccination though it is very rare. The facility at which vaccination is given should be ready to manage the anaphylaxis with necessary equipments and skilled personnel.

What cautions are needed with Tresivac (pfs) vaccine?

  • The facility to management anaphylaxis should be ready while giving this injection.
  • The caution should be taken in those who are allergic egg proteins.
  • The vaccine should not be given to those who are allergic to any of its components.
  • This is live vaccine so cannot be used in pregnancy.
  • The pregnancy should be avoided till after 3 months of giving this vaccine, though this vaccine is not valid indication for abortion.
  • The caution should be taken in immmunocompromised patients. The vaccine is used in them if benefit outweighs the risks.
  • In infants of HIV mothers this vaccine should be given as early as after 6 months of age.
  • The vaccine is avoided in those with active TB disease or those in intensive phase of the TB-treatment.
  • The vaccine should be given after one month to those who got measles as the natural disease does not given immunity.
  • Biomedical waste management guidelines are to be followed like all other vaccinations.
  • The vaccine is stored as per mentioned on packet by the manufacturer.

To whom Tresivac (pfs) vaccine is contraindicated?

  • Tresivac pfs vaccine is contraindicated in those with stage 3 or stage 4 HIV AIDS disease.
  • Tresivac pfs vaccine is contraindicated those who are severely immunocompromized.
  • Those who are pregnant.
  • Those who are allergic to any of its component.
  • Those who got anaphylaxis at the time of Tresivac pfs vaccine in past.
  • Those who are allergic to egg protein should get this vaccine under monitoring of allergiests.

What is difference between Tresivac and Tresivac Pfs vaccine?

Recently Serum institute of India has upgraded the product tresivac.

Previously Tresivac was available as dried lyophilized powder in one vial and sterile water diluent in other vial.

Now Tresivac pfs has lyophilized powder in a vial and sterile water as diluent in pre filled syringe.

With this arrangement the chances of contamination while preparing i.e reconstituting vaccine are decreased to a large extent.

Other brands for MMR vaccine

Following are other brands available alternate to Tresivac (pfs) vaccine:

<span class="has-inline-color has-luminous-vivid-orange-color">Dr Yatin Bhole MBBS DCh DNB</span>
Dr Yatin Bhole MBBS DCh DNB

This article was written by Dr Yatin Bhole who is practicing Pediatrician at Bhole Children Clinic, Ravet. This post is for general information and before applying it on yourself, you should meet your doctor or meet us in person.

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4 thoughts on “Tresivac (pfs) vaccine (MMR Vaccine)”

  1. Thanks for this informative article, Dr Yatin. I wasn’t sure if we should take the Tresivac normal vaccine or Tresivac PFS. Your article helps to clarify! The price of the PFS vaccine is three times the cost of the normal Tresivac vaccine.

  2. Ok. Thank you. It also means more ₹₹₹ for Serum. 😉

    I am taking this vaccine given the yet unproven but clear co-relation between MMR-vaccinated people have quicker covid recovery (by a reduced or non-existent) cytokinine storm. 🙂


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