Jenvac vaccine

Jenvac vaccine

Jenvac vaccine is a Japanese encephalitis vaccine by Bharat biotech JENVAC is a single dose inactivated Japanese Encephalitis (JE) Vaccine. This Vero cell derived vaccine is prepared from an Indian strain (Kolar- 821564XY) of the JE virus. JENVAC has been developed in collaboration with the National Institute of Virology, India. It is a safe and highly-effective vaccine that protects against all known strains of Japanese Encephalitis..

How is Jenvac vaccine available?

Jenvac vaccine is available as ready to inject liquid form. It is available as 0.5 ml pre-filled syringe. The vaccine looks hazy and becomes homogenous when shaken. It is also available in 0.5 ml vial made up of glass with aluminium sealed rubber stopper.

How is Jenvac vaccine stored?

Jenvac vaccine is stored at 2-8 degree Celsius. The temperature range is maintained as per standard cold chain. The temperature range is maintained at all stages of transport and storage. The vaccine if accidentally frozen should be discarded. 

To whom Jenvac vaccine is indicated?

· This vaccine is given to those people who are staying in endemic areas of the Japanese encephalitis. 

· It is also given to people who are going to visit the endemic areas. The vaccination should be complete atleast 7 days before the exposure.

· Those who are below 15 years should get this vaccine on priority basis.

How is Jenvac vaccine given?

This vaccine is given by injection on thigh on anterolateral aspect in small children. The dose for 1-3 years is 0.25 ml and for more than 3 years old is 0.5 ml. All the necessary safety injection precautions should be taken and the disposables are disposed as per biological waste management protocol. The expired vaccine should be discarded as per BMW protocols. The vaccine should be given intramuscular it should not be given intravenous.

At what age Jenvac vaccine is given?

  • Jenvac vaccine is given to those in endemic area in routine immunization at above age 1 years 0.5 ml single dose. Generally given at age 13 months. The booster can be given after 1 year if the first dose was given Jenvac vaccine.
  • Currently IAP recommends 2 doses atleast 28 days apart.
  • If first dose of Jenvac was taken it is recommended that subsequent doses should be bu Jenvac vaccine.
  • Jenvac vaccine is also given to people who are planning to visit the endemic areas. The vaccination should be completed at least 7 days before exposure.
  • ·Data of 2-dose study shows that a single dose of JENVAC is sufficient to elicit the immune response as the subjects who received a single dose were 98.67% sero-protected and the 4-fold sero-conversion was at 93.14% for the ≥1 year to ≤50 years age group.

How does Jenvac vaccine works?

Jenvac vaccine works as active immunization. The person to whom the vaccine is given gets antigen of Japanese encephalitis. These are killed virus derived antigens. The immune system of the person recognizes these antigens and develops the immune mechanism to fight against it. When the real infection occur the immune system rapidly ramps the immune response and the disease is prevented. In the process the memory immunity is produced which lasts longer. Yet the need of boosters is undetermined it is unknown how many years this immunity lasts.

What are side effects of Japanese encephalitis vaccine?

The side effects of Japanese encephalitis vaccine This vaccine are usually mild as compared to disease. They can be easily managed at home.

  • Fever may occur after vaccination and can last for 1-3 days. It can be moderate grade fever. It can be easily managed by paracetamol and sponging at home.
  • Local pain and swelling can occur after the vaccination. This can last for 3 days and can be reduced by paracetamol and local cold compression.
  • Decreased appetite, somnolence and rash may occur after the vaccination in few children. It usually subsides by its own and is generally mild form.
  • Hypersensitivity reaction may occur after this vaccination like any other injection. The facility where vaccination is done should be equipped with necessary drugs and personnel with skill to manage the anaphylaxis reaction.

To whom Jenvac vaccine should not be given?

  • This vaccine should not be given to person who is allergic to any of its components. This vaccine should not be given to those who had got hypersensitivity reaction and anaphylaxis at first dose.
  • There are very few contraindications to this vaccine.
  • nfants younger than 2 months should not be administered JE vaccine 
  • People who have had a life-threatening allergic reaction to the JE vaccine or any ingredient in the vaccine 
  • Have serious allergies of any kind 
  • If the subject is are pregnant

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